Changelog
What's New in Gene2AI
We ship updates every week. All features are free during Early Access.
Featurev5.2March 14, 2026
Medical Imaging Auto-Extraction & Cross-Page Description Matching
- •Auto-detect imaging pages (ultrasound, CT, X-ray, ECG, bone density, fundus) in checkup report PDFs
- •Each imaging exam is extracted as a separate document with the original page image uploaded to S3
- •Cross-page description matching: LLM matches imaging pages with their text descriptions from anywhere in the report
- •Auto-created imaging documents are linked to parent checkup report with 'Auto-extracted' badge
- •Cascade deletion: deleting a parent report also removes all child imaging documents and S3 assets
- •Health Profile API now includes imaging findings in the unified summary endpoint
Milestonev5.1March 12, 2026
CGM Time-Series Data, Dashboard Cross-Reference & Family Profiles
- •CGM (Continuous Glucose Monitoring) support: upload Sibionics xlsx files for structured glucose analytics
- •Time-series framework: streams, data points, daily summaries, and period summaries with TIR, GMI, CV metrics
- •Dashboard CGM panel: average glucose, Time in Range, GMI, and 10-day trend chart
- •Cross-reference analysis: correlate genomic risk factors (e.g., Type 2 Diabetes) with lab results and CGM data
- •Unified upload entry: auto-detect CGM files vs genomic files vs health documents from a single upload button
- •Time-series data integrated into Health Data page as a new 'Time Series' tab
- •Health Profile API extended with timeSeriesData field for AI agent access
- •Family health profiles: manage multiple family members under one account with per-person data isolation
- •Cascading delete for health documents: records, findings, jobs, S3 files, and API keys all cleaned up
- •Health Profile summary mode: compact conclusions-only JSON (~2-4KB) for efficient AI agent conversations
Milestonev5.0March 8, 2026
Knowledge Base v5.0 — 122K+ SNPs, Re-analyze & Profile-Scoped Keys
- •Upgraded to Gene2AI Knowledge Base v5.0-gwas-cpic: 122,896 SNP markers across 6,491 genes in 11 categories (131x increase from v3.5)
- •Re-analyze feature: re-submit genomic files to get fresh analysis with the latest KB — single job or batch re-analyze all
- •API Keys are now profile-scoped: each key is bound to a specific health profile for multi-family data isolation
- •Export filenames now include profile name for easy identification
- •Batch insert chunking: large genomic imports (17K+ records) now reliably complete without MySQL limits
- •Guide page: new Re-analyze vs Refresh documentation section
- •SEO metadata updated to reflect v5.0 knowledge base stats
Featurev4.3March 5, 2026
API v3.5 Sync — 9 Categories, Dashboard Overhaul & Refresh
- •Synced with Gene2AI API v3.5: 933 SNP markers, 273 genes, 363 LD proxies across 9 analysis categories
- •4 new genomic categories: APOE genotyping (ε2/ε3/ε4), HLA allele typing (9 alleles), CYP450 metabolizer phenotyping (CPIC), NAT2 acetylator typing
- •5-tier health risk levels: low, average, slightly_elevated, elevated, high
- •Drug response now includes PharmGKB + CPIC data (192 markers, up from 162)
- •Dashboard overhaul: health risk overview panel, genomic risk summary, cross-reference insights (genomic ↔ lab data)
- •Genomic record cards redesigned: structured display with risk color-coding, phenotype badges, expandable details
- •HealthDataDetail: risk summary panel with elevated/low filter, groups sorted by risk priority
- •Refresh Analysis: re-fetch latest results from api.gene2.ai (single job or batch refresh all)
- •Direct .zip file upload support (no auto-compression needed)
- •Mobile UX improvements: larger touch targets, stacked layouts, better footer spacing
Improvementv4.2March 3, 2026
Direct Upload & Gene2AI API Migration
- •Migrated all genomic analysis to Gene2AI's unified API (api.gene2.ai) — removed legacy WeGene API dependency
- •Frontend now uploads files directly to Gene2AI via presigned URLs, bypassing gateway size limits
- •Supports large genomic files via ZIP compression (up to 100MB) — compress your raw data before uploading for best results
- •Three-step upload flow: prepare → direct upload → confirm for maximum reliability
Featurev4.1March 3, 2026
WeGene (微基因) Support
- •Added WeGene as a supported genomic data source alongside 23andMe and AncestryDNA
- •Auto-detection of WeGene files by filename pattern
- •WeGene data format passed through to analysis engine for optimized parsing
- •Updated all upload interfaces (Upload page, Upload dialog) with WeGene option
Featurev4.0February 28, 2026
Trend Charts & Mobile Optimization
- •Interactive trend charts for numeric health indicators (line chart with reference range shading)
- •Trend overview on Health Data Vault page — prioritizes abnormal indicators
- •Optimized Health Data detail page for mobile (stacked layout, collapsible doc preview, compact spacing)
- •Backend API for indicator trend data (GET /api/v1/health/trends)
Improvementv3.5February 24, 2026
Unified Health Data Architecture
- •Unified upload: accept genomic files (.txt/.csv) and health documents (PDF/images) from a single Upload button
- •Auto-detect file type — genomic files route to analysis, health documents to AI parsing
- •Unified My Jobs page: merged genomic analysis tasks and document parsing tasks in one view
- •Unified API Keys: single user-scoped key for all health data (genomic + medical + self-reported)
- •Streamlined navigation and entry points across the app
Featurev3.2February 20, 2026
Health Data Vault — Agent API & OpenClaw Skill
- •Agent file upload API (POST /api/v1/health-data/upload) — upload documents from chat agents
- •Agent structured data submission (POST /api/v1/health-data/records) — record metrics via API
- •Agent document status query (GET /api/v1/health-data/doc/:id) — poll parse progress
- •OpenClaw Skill v2.0 — upload health docs, record daily metrics, query health data via Telegram/Feishu
- •Source tracking for multi-channel data collection (web, openclaw, telegram, etc.)
Milestonev3.1February 17, 2026
Health Data Vault
- •New Health Data Vault page (/health-data) — centralized view of all health documents and records
- •AI-powered document parsing: upload lab reports, checkup results, medical records (PDF/images) and get structured data
- •Manual health data entry with step wizard and date emphasis
- •Document detail page with split view: original document + extracted results table
- •Auto-import genomic analysis results into Health Data Vault on completion
- •User-scoped API keys with Bearer token authentication for AI agents
- •Agent Health Data API: full records, delta sync, and summary endpoints
- •Category filtering, search, and document management (edit/delete)
Milestonev3.0February 10, 2026
Major Expansion — 903 SNP Markers
- •Expanded from 37 to 903 curated SNP markers across 269 genes
- •Health Risks: 90 conditions analyzed (365 markers) — cardiovascular, cancer, diabetes, neurological & more
- •Drug Response: 52 drug interactions (162 markers) — Warfarin, Clopidogrel, Statins, SSRIs & more
- •Traits: 43 genetic traits (158 markers) — caffeine metabolism, alcohol flush, muscle fiber type & more
- •Nutrition: 37 nutrient insights (166 markers) — Vitamin D, Folate, Omega-3, Iron, Calcium & more
- •Ancestry: population composition (52 markers) with regional breakdowns
- •Population-aware analysis across 5 populations: EUR, EAS, AFR, SAS, AMR
- •221 LD proxy variants (R² ≥ 0.7) for maximum chip coverage
- •Multi-chip support: 23andMe V3/V4/V5, AncestryDNA V1/V2, WeGene
- •LLM-enriched descriptions with confidence scores and population-specific notes
Milestonev0.2.1February 3, 2026
Early Access Launch
- •Launched Early Access — all future updates included free
- •37+ curated SNP markers across 5 categories: health risks, drug response, traits, nutrition, ancestry
- •AI-Ready JSON output with structured, machine-readable format
- •API key system for AI agent integration (ChatGPT, Claude, OpenClaw, custom bots)
- •Support for 23andMe and AncestryDNA raw data files (.txt, .csv, .zip)
- •LLM-enriched descriptions with clinical significance and confidence scores
Improvementv0.2.0January 27, 2026
Migrated to Self-Built Analysis Engine
- •Switched to Gene2AI's own analysis API (api.gene2.ai) — all genomic data now processed through our unified pipeline
- •Improved analysis pipeline with better SNP matching and genotype interpretation
- •Added comprehensive error handling and retry logic for analysis jobs
Coming Up
Here's what's on the roadmap. All included free during Early Access.
v0.7Month 3
Polygenic Risk Scores
Multi-gene risk models, combined genetic + clinical assessment from Health Data Vault
v0.8Month 4
Ancestry + LLM Insights
Regional ancestry breakdown, LLM-powered actionable insights, personalized recommendations
v0.9Month 6
More Wearables & Multi-Omics
Apple Health, Oura Ring, Whoop integration. WGS support, DNA methylation, and metabolomics data
v1.0Month 9
Full Release
20,000+ SNPs, 50+ PRS models, 100+ drugs, 30+ supplements, integrated multi-omics health platform